| Authors |
Carty JS, Selvasingh J, Zuchowski Y, Nam HJ, Pénalva C, Nanayakkara G, Jennings
EQ, Voss K, Adame ET, Tossberg JT, Yap WS, Melzer M, Viquez O, McCall AS,
Piotrowski ER, Bessho R, Cao S, Leaptrot KL, Schrimpe-Rutledge AC, Codreanu SG,
Sherrod SD, McLean JA, Trapani JB, Cottam MA, Wan M, Shrivastava D, Delker DA,
Wilson MH, Hasenour CM, Lantier L, Chernova I, Young JD, Haase VH,
Vazquez-Medina JP, Kosma DK, Kim PK, Cartailler JP, Zhang M, Zent R, Harris RC,
Watts JA, Terker AS, Bock F, Rathmell JC
|
| Submitted By |
Juan Arroyo Ornelas on 10/19/2026 |
| Status |
Published |
| Journal |
Nature communications |
| Year |
2026 |
| Date Published |
5/25/2026 |
| Volume : Pages |
17 : Not Specified |
| PubMed Reference |
42185304 |
| Abstract |
Lipids can be considered a water reservoir used to offset dehydration stress as
their oxidation by the mitochondria generates water. However, whether
dehydration and the ensuing hypertonic stress directly regulate lipid synthesis
is unknown. We show that hypertonic stress decreases cellular oxygen
consumption, increases intracellular lipid synthesis, and favors glutamine
oxidation as a carbon precursor for lipid synthesis via remodeling mitochondrial
metabolism. These findings provide a mechanism whereby cellular dehydration
leads to intracellular lipid accumulation, functionally linking water
availability to lipid storage.
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